Long Pentraxin 3/TSG-6 Interaction: a Biological Rheostat for Fibroblast Growth Factor 2-Mediated Angiogenesis

摘要

ObjectiveAngiogenesis is regulated by the balance between pro- and anti-angiogenic factors and by extracellular matrix protein interactions. Fibroblast growth factor-2 (FGF2) is a major pro-angiogenic inducer inhibited by the interaction with the soluble pattern recognition receptor long pentraxin 3 (PTX3). PTX3 is locally co-expressed with its ligand TSG-6, a secreted glycoprotein that co-operates with PTX3 in extracellular matrix assembly. Here, we characterized the effect of TSG-6 on PTX3/FGF2 interaction and FGF2-mediated angiogenesis.