Peri-operative Plasma F2-Isoprostane Levels Correlate with Markers of Impaired Ventilation in Infants with Single Ventricle Physiology Undergoing Stage II Surgical Palliation on Cardiopulmonary Bypass

摘要

IntroductionCardiopulmonary bypass (CPB) produces inflammation and oxidative stress which contribute to post-operative complications following cardiac surgery. F2-Isoprostanes (F2-IsoPs) are products of lipid oxidative injury and represent the most accurate markers of oxidative stress. CPB is associated with elevated IsoPs in adults undergoing cardiac surgery. The relationship between F2-IsoPs and peri-operative end-organ function in infants with single ventricle physiology, however, has not been well studied.