Activity in varicosities within the myenteric plexus between and during the colonic migrating motor complex in the isolated murine large intestine

摘要

BackgroundNeuronal communication within the myenteric plexus occurs when action potentials along nerve fibers produce Ca²⁺ transients in varicosities leading to exocytosis of vesicles and neurotransmitters release. We used Ca²⁺ transients in varicosities to monitor action potential activity in myenteric nerve pathways both between and during the colonic migrating motor complex (CMMC) in the isolated murine colon.