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Effects of an Agonist IL-2/Fc Fusion Protein A Mutant Antagonist IL-15Fc Fusion Protein and Sirolimus on Cardiac Allograft Survival in Non-Human Primates

机译：激动剂IL-2 / FC融合蛋白突变体拮抗性IL-15FC融合蛋白和西罗司对非人印象的心脏异种移植存活蛋白质的影响

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摘要

BackgroundTo tilt the immunologic balance towards tolerance and away from rejection, nonhuman primate recipients of cardiac allografts were treated with IL-2/Fc, mutant antagonist type (m) IL-15/Fc and sirolimus.

机译：背景技术将免疫平衡倾向于耐受性，远离排斥，心脏同种异体移植物的非人类动物激素接受者用IL-2 / Fc，突变拮抗剂型（M）IL-15 / Fc和西罗司处理。

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期刊名称 other
作者
Timothy Millington; Maria Koulmanda; Choo Ng; Svjetlan Boskovic; Ognjenka M. Nadazdin; Gilles Benichou; Xin Xiao Zheng; Terry B. Strom; Joren C. Madsen;
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年(卷),期 -1(31),4
年度 -1
页码 427–435
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
heart transplantation IL-15 primates rejection;

机译：心脏;移植;IL-15;灵长类动物;排斥反应;

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专利

1. Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates [J] . MillingtonT., KoulmandaM., NgC., The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation . 2012,第4期

机译：激动剂白介素-2 / Fc融合蛋白，突变体拮抗剂白介素-15 / Fc融合蛋白和西罗莫司对非人类灵长类动物心脏同种异体移植存活的影响
2. Short course single agent therapy with an LFA-3-IgG1 fusion protein prolongs primate cardiac allograft survival. [J] . Kaplon RJ, Hochman PS, Michler RE, Transplantation: Official Journal of the Transplantation Society . 1996,第3期

机译：LFA-3-IgG1融合蛋白的短程单药疗法可延长灵长类动物心脏同种异体移植的存活时间。
3. 691?MDK-271: A dual function molecule consisting of empirically-designed peptidyl agonists of IL-2/15Rβγc and IL-7Rαγc, unrelated to IL-2, IL-15, or IL-7, incorporated into a bispecific Fc fusion protein [J] . William Dower, Steven Cwirla, Alice Bakker, Journal for ImmunoTherapy of Cancer . 2020,第Suppla3期

机译：691？MDK-271：一种由IL-2 /15RβγC和IL-7RαγC的经验设计的肽基激动剂组成的双函数分子，与IL-2，IL-15或IL-7无关，其掺入双特异性FC融合蛋白中
4. Quantitative Proteomics in Combination with Immunomics Reveals Morphine-Produced Immunosuppressive Effects at the Protein and Cellular Levels in Non-human Primates [C] . Joseph N. Brown, Gabriel M. Ortiz, Thomas E. Angel, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：与免疫组合的定量蛋白质组学表现出在非人最初的蛋白质和细胞水平的吗啡产生的免疫抑制作用
5. Complex stability behavior in novel protein constructs: Aggregation of FC- and HSA- based fusion proteins. [D] . Cordes, Amanda Ann. 2011

机译：新型蛋白质构建物中的复杂稳定性行为：基于FC和HSA的融合蛋白的聚集。
6. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway [O] . Alan J. Bitonti, Jennifer A. Dumont, Susan C. Low, 2004

机译：通过免疫球蛋白转运途径在非人灵长类动物中肺促红细胞生成素Fc融合蛋白的肺部递送
7. Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates [O] . Timothy Millington, Maria Koulmanda, Choo Ng, 2012

机译：激动剂白细胞介素-2 / Fc融合蛋白，突变体拮抗剂白细胞介素-15 / Fc融合蛋白和西罗莫司对非人类原始生物生存期的影响

Effects of an Agonist IL-2/Fc Fusion Protein A Mutant Antagonist IL-15Fc Fusion Protein and Sirolimus on Cardiac Allograft Survival in Non-Human Primates

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