The Banff 2009 Working Proposal for Polyomavirus Nephropathy: A Critical Evaluation of its Utility as a Determinant of Clinical Outcome

摘要

Clinical outcome in BK virus nephropathy(BKVN) was examined in relation to clinical and histologic parameters with reference to the Banff Working Proposal 2009, which emphasizes tubular injury and viral load. 71 patients were evaluated in three eras: (a) Era-I: No BKV PCR performed(n=36), (b) Era-II: PCR performed for rising creatinine(n=24), and (c) Era III: PCR performed for routine screening(n=11). 6/71(8.4%) patients were classified as Class A, 46/71(64.8%) as Class B and 19/71(26.8%) as Class C. Banff class A never occurred in era-I. It is a heterogeneous class that includes biopsies with inflammation that have hitherto been included in Class B. Higher inflammation, but not tubular injury, nor histologic viral load correlated with worse creatinine at 3 months. On long-term follow-up, class C associated with graft loss (hazard ratio 2.45, p=0.03). Clearance of viremia was associated with better graft survival at 5 years (46.0% versus 25.0%). Viruria clearance was infrequent (15.6%). In conclusion, the clinical utility of the Banff Working Proposal 2009 derives from scoring of fibrosis and not extent of tubular injury or viral cytopathic effect. The proposal is not superior to existing schemas that include assessment of inflammation, which is a well-known prognostic marker in other renal allograft diseases.