Both High Level Pressure Support Ventilation and Controlled Mechanical Ventilation Induce Diaphragm Dysfunction and Atrophy

摘要

RationalePrevious workers have demonstrated that controlled mechanical ventilation (CMV) results in diaphragm inactivity and elicits a rapid development of diaphragm weakness due to both contractile dysfunction and fiber atrophy. Limited data exist regarding the impact of pressure support ventilation (PSV),a commonly used mode of mechanical ventilation--that permits partial mechanical activity of the diaphragm—on diaphragm structure and function.