Controlled Pauses at the Initiation of Sodium Nitroprusside Enhanced CPR Facilitate Neurological and Cardiac Recovery after 15 Minutes of Untreated Ventricular Fibrillation

摘要

ObjectiveA multi-pronged approach to improve vital organ perfusion during cardiopulmonary resuscitation (CPR) that includes sodium nitroprusside (SNP), active compression-decompression (ACD)-CPR, an impedance threshold device, and abdominal pressure (SNPeCPR) has been recently shown to increase coronary and cerebral perfusion pressures and higher rates of return of spontaneous circulation (ROSC) versus standard CPR. To further reduce reperfusion injury during SNPeCPR we investigated the addition of adenosine and four 20-second controlled pauses (CP) spread throughout the first 3 minutes of SNPeCPR. The primary study endpoint was 24-hour survival with favorable neurological function after 15 minutes of untreated ventricular fibrillation. (VF)