Intravenous Acetate Elicits a Greater Free Fatty Acid Rebound in Normal than Hyperinsulinaemic Humans

摘要

Background/ObjectivesColonic fermentation of dietary fiber may improve insulin sensitivity via the metabolic effects of short chain fatty acids (SCFA) in reducing free fatty acids (FFA). The main objectives of this study were to compare peripheral uptake of acetate (AC) in participants with normal (< 40pmol/L, NI) and high (≥ 40pmol/L, HI) plasma-insulin and the ability of AC to reduce FFA in both groups.