Modulating lncRNA SNHG15/CDK6/miR-627 circuit by palbociclib overcomes temozolomide resistance and reduces M2-polarization of glioma associated microglia in glioblastoma multiforme

摘要

BackgroundAccumulating evidence demonstrates the oncogenic roles of lncRNA (long non-coding RNA) molecules in a wide variety of cancer types including glioma. Equally important, However, tumorigenic functions of lncRNA in glioma remain largely unclear. A recent study suggested lncRNA SNHG15 played a role for regulating angiogenesis in glioma but its role in the tumor microenvironment (TME) was not investigated.