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Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine

机译：Memantine和Dizocilpine与吗啡急性或慢性治疗与吗啡急性或慢性治疗后吗啡的抗闭合性或辨别刺激作用的相互作用

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摘要

RationaleMemantine is a N-methyl-d-aspartic acid receptor (NMDAR) channel blocker that binds to dizocilpine sites and appears well tolerated during chronic use. Published studies suggest NMDAR antagonists prevent development of tolerance to effects of morphine by blocking NMDAR hyperactivation.

机译：RationaleMemantine是一种N-甲基-d-天冬氨酸受体（NMDAR）通道阻滞剂，可与地佐西平位点结合并在长期使用中表现出良好的耐受性。已发表的研究表明，NMDAR拮抗剂可通过阻止NMDAR过度活化来阻止对吗啡作用的耐受性的发展。

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期刊名称 other
作者
Yukun Chen; Marianne Evola; Alice M. Young;
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年(卷),期 -1(225),1
年度 -1
页码 187–199
总页数 24
原文格式 PDF
正文语种
中图分类
关键词
Memantine Dizocilpine Morphine Antinociception Drug discrimination Tolerance;

机译：美金刚;地佐西平;吗啡;抗伤害感受;药物歧视;耐受性;

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专利

1. Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine [J] . ChenY., EvolaM., YoungA.M. Psychopharmacology . 2013,第1期

机译：美金刚和地佐西平在吗啡急性或慢性治疗后与吗啡的抗伤害性或区分性刺激作用
2. Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine [J] . ChenY., EvolaM., YoungA.M. Psychopharmacology . 2013,第1期

机译：Memantine和Dizocilpine与急性或慢性治疗与吗啡急性或慢性治疗后吗啡的抗血质或歧视性刺激作用的相互作用
3. Interactions of acute morphine with chronic imipramine and fluvoxamine treatment on the antinociceptive effect in arthritic rats. [J] . Gutierrez M, Ortega Alvaro A, Gibert Rahola J, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2003,第1期

机译：急性吗啡与慢性丙咪嗪和氟伏沙明治疗对关节炎大鼠镇痛作用的相互作用。
4. NEUROCHEMICAL CHANGES IN PREFRONTAL CORTEX AND HIPPOCAMPUS OF RAT INDUCED BY CHRONIC MORPHINE ADMINISTRATION AND WITHDRAWAL STUDIED BY HIGH RESOLUTION 1H NMR SPECTROSCOPY [C] . . 2005

机译：高分辨率吗啡经1H NMR对慢性吗啡给药和戒断所致大鼠前皮质和海马的神经化学变化
5. ENVIRONMENTAL MODIFICATION OF TOLERANCE TO MORPHINE DISCRIMINATIVE STIMULUS PROPERTIES (RATS, FADING, CUMULATIVE DOSING, GENERALIZATION, BEHAVIOR) [D] . SANNERUD, CHRISTINE ANNE. 1985

机译：对吗啡区分刺激物特性（大鼠，衰落，累积剂量，一般化，行为）的耐受性的环境变化
6. The discriminative stimulus effects of midazolam are resistant to modulation by morphine amphetamine dizocilpine and γ-butyrolactone in rhesus monkeys [O] . Xiang Bai, Charles P. France, Lisa R. Gerak -1

机译：咪达唑仑的鉴别刺激效应对吗啡安非他明Dizocilpine和γ-丁内酯在恒河猴中的调节抵抗力
7. Effects of Direct- and Indirect-Acting Serotonin Receptor Agonists on the Antinociceptive and Discriminative Stimulus Effects of Morphine in Rhesus Monkeys [O] . Li, Jun-Xu, Koek, Wouter, Rice, Kenner C, 2011

机译：直接和间接作用的5-羟色胺受体激动剂对吗啡在恒河猴中的抗伤害感受性和判别性刺激作用的影响
8. Examination of Acute Sensitivity to Morphine and Morphine Self- Administration Following Physical and Environmental Stressors in Fischer-344 and Lewis Female Rats. [R] . Brown, K. 1997

机译：在Fischer-344和Lewis雌性大鼠中观察物理和环境应激物对吗啡和吗啡自身给药的急性敏感性。

Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine

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