Data Analysis in Emission Tomography Using Emission–Count Posteriors

摘要

A novel approach to analysis of emission tomography data using the posterior probability of the numbers of emissions per voxel (emission–count) conditioned on acquired tomographic data is explored. The posterior is derived from the prior and the Poisson likelihood of the emission–count data by marginalizing voxel activities. Based on emission–count posteriors, examples of Bayesian analysis including estimation and classification tasks in emission tomography are provided. The application of the method to computer simulations of 2D tomography is demonstrated. In particular, the minimum–mean–square–error (MMSE) point estimator of the emission–count is demonstrated. The process of finding this estimator can be considered as a tomographic image reconstruction technique since the estimates of the numbers of emissions per voxel divided by voxel sensitivities and acquisition time are the estimates of the voxel activities. As an example of a classification task, a hypothesis stating that some region of interest (ROI) emitted at least or at most r–times the number of events in some other ROI is tested. The ROIs are specified by the user. The analysis described in this work provides new quantitative statistical measures that can be used in decision making in diagnostic imaging using emission tomography.