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Protected Graft Copolymer Excipient Leads to a Higher Acute Maximum Tolerated Dose and Extends Residence Time of Vasoactive Intestinal Peptide Significantly Better than Sterically Stabilized Micelles

机译：受保护的接枝共聚物赋形剂导致更高的急性最大耐受剂量并延长血管活性肠肽的停留时间明显优于空心稳定的胶束

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摘要

PurposeTo determine and compare pharmacokinetics and toxicity of two nanoformulations of Vasoactive Intestinal Peptide (VIP).

机译：目的确定和比较血管活性肠肽（VIP）的两种纳米制剂的药代动力学和毒性。

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期刊名称 other
作者
Sandra Reichstetter; Gerardo M. Castillo; Israel Rubinstein; Akiko Nishimoto-Ashfield; ManShun Lai; Cynthia C. Jones; Aryamitra Banjeree; Alex Lyubimov; Duane C. Bloedow; Alexei Bogdanov Jr.; Elijah M. Bolotin;
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年(卷),期 -1(30),3
年度 -1
页码 670–682
总页数 27
原文格式 PDF
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关键词
long-acting vasoactive intestinal peptide maximum tolerated dose nanocarrier protected graft copolymer sterically stabilized micelles;

机译：长效血管活性肠肽;最大耐受剂量;纳米载体;受保护的接枝共聚物;空间稳定的胶束;

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外文文献

1. Erratum: Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal peptide significantly better than sterically stabilized micelles (Pharmaceutical Research DOI:10.1007/s11095-012-0904-4) [J] . ReichstetterS., CastilloG.M., RubinsteinI., Pharmaceutical research . 2013,第7期

机译：勘误：受保护的接枝共聚物赋形剂导致更高的急性最大耐受剂量并延长了血管活性肠肽的停留时间，明显优于空间稳定的胶束（Pharmaceutical Research DOI：10.1007 / s11095-012-0904-4）
2. Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles. [J] . Sandra Reichstetter, Gerardo M Castillo, Israel Rubinstein, Pharmaceutical research . 2013,第3期

机译：受保护的接枝共聚物赋形剂导致更高的急性最大耐受剂量，并延长血管活性肠肽的停留时间，明显优于空间稳定的胶束。
3. Extending residence time and stability of peptides by protected graft copolymer (PGC) excipient: GLP-1 example. [J] . Gerardo M Castillo, Sandra Reichstetter, Elijah M Bolotin Pharmaceutical research . 2012,第1期

机译：通过受保护的接枝共聚物（PGC）赋形剂延长肽的停留时间和稳定性：GLP-1示例。
4. Extending residence time and stability of peptides by Protected Graft Copolymer (PGC) excipient: GLP-1 example [O] . Gerardo M. Castillo, Sandra Reichstetter, Elijah M. Bolotin -1

机译：通过保护接枝共聚物（PGC）赋形剂（PGC）延伸肽的停留时间和稳定性：GLP-1实施例
5. Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles [O] . Reichstetter, Sandra, Castillo, Gerardo M., Rubinstein, Israel, 2013

机译：受保护的接枝共聚物赋形剂导致更高的急性最大耐受剂量并且延长血管活性肠肽的停留时间明显优于空间稳定的胶束

Protected Graft Copolymer Excipient Leads to a Higher Acute Maximum Tolerated Dose and Extends Residence Time of Vasoactive Intestinal Peptide Significantly Better than Sterically Stabilized Micelles

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