Phase II Study of Preoperative Radiation with Concurrent Capecitabine Oxaliplatin and Bevacizumab Followed by Surgery and Postoperative 5-FU Leucovorin Oxaliplatin (FOLFOX) and Bevacizumab in Patients with Locally Advanced Rectal Cancer: ECOG 3204

摘要

BackgroundRecent studies have demonstrated the feasibility of combining oxaliplatin with 5-FU or capecitibine and radiation therapy (RT). The addition of bevacizumab to chemotherapy improves overall survival for metastatic disease. We initiated a phase II trial to evaluate preoperative capecitabine, oxaliplatin, and bevacizumab with RT followed by surgery and postoperative 5-FU, leucovorin, oxaliplatin (FOLFOX) and bevacizumab for locally advanced rectal cancer.