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Metformin Impairs Vascular Endothelial Recovery After Stent Placementin the Setting of Locally Eluted Mammalian Target of Rapamycin Inhibitors Via S6Kinase-Dependent Inhibition of Cell Proliferation

机译：二甲双胍在支架放置后损害血管内皮恢复在局部洗脱的哺乳动物抑制剂靶催化剂的设置通过S6激酶依赖性抑制细胞增殖

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摘要

ObjectivesThis study sought to examine the effect of oral metformin (Mf) therapy on endothelialization in the setting of drug-eluting stents (DES).

机译：目的本研究旨在探讨口服二甲双胍（Mf）治疗对药物洗脱支架（DES）的内皮化作用。

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期刊名称 other
作者
Anwer Habib; Vinit Karmali; Rohini Polavarapu; Hirokuni Akahori; Masataka Nakano; Saami Yazdani; Fumiyuki Otsuka; Kim Pachura; Talina Davis; Jagat Narula; Frank D. Kolodgie; Renu Virmani; Aloke V. Finn;
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年(卷),期 -1(61),9
年度 -1
页码 971–980
总页数 19
原文格式 PDF
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关键词
cell proliferation drug-eluting stents endothelium metformin S6K;

机译：细胞增殖;药物洗脱支架;内皮;二甲双胍;S6K;

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专利

1. Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted Mammalian target of rapamycin inhibitors via s6 kinase-dependent inhibition of cell proliferation. [J] . Anwer Habib, Vinit Karmali, Rohini Polavarapu, Journal of the American College of Cardiology . 2013,第9期

机译：二甲双胍通过s6激酶依赖性细胞增殖抑制作用，在放置雷帕霉素抑制剂的局部洗脱哺乳动物靶点的情况下，损害了支架置入后血管内皮的恢复。
2. The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1 alpha signaling pathway in ELT-3 cells [J] . Tadakawa Mad, Takeda Takashi, Li Bin, Molecular and Cellular Endocrinology . 2015,第3期

机译：抗糖尿病药物二甲双胍通过哺乳动物雷帕霉素复合物1 /低氧诱导因子-1α信号通路的哺乳动物靶点抑制血管内皮生长因子的表达
3. MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin [J] . Zhang Zi-wei, Guo Rui-wei, Lv Jin-lin, Biochemical and Biophysical Research Communications . 2017,第2期

机译：通过抑制胰岛素样生长因子-1受体和哺乳动物的雷帕霉素，抑制胰岛素诱导的胰岛素诱导的增殖，迁移，去生和抗血管平滑肌细胞的雷帕霉素抗性
4. Gefitinib, as a New Stent Coating Material, Specifically Inhibits Smooth Muscle Cells Proliferation Through Inhibition of EGFR/Akt Pathway Phosphorylation [C] . F. Li, S. Y. Wang, J. Luo, International Conference on Power Electronics and Energy Engineering . 2015

机译：作为新的支架涂层材料，吉非替尼特异性地通过抑制EGFR / AKT途径磷酸化来抑制平滑的肌细胞增殖
5. Rapamycin and Adiponectin in Vascular Smooth Muscle Cells: Implications in the Development of Drug-Eluting Stents. [D] . Ding, Min. 2011

机译：雷帕霉素和脂联素在血管平滑肌细胞：药物洗脱支架的发展中的意义。
6. Outcomes of Unselected Patients with Metastatic Clear-Cell Renal Cell Carcinoma Treated with Front-Line Pazopanib Therapy Followed by Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors (VEGFR-TKI) or Mammalian Target of Rapamycin Inhibitors (mTORi): A Single Institution Experience [O] . Marc R. Matrana, Tharakeswara Bathala, Matthew T Campbell, -1

机译：一线帕唑帕尼治疗后再行血管内皮生长因子受体酪氨酸激酶抑制剂（VEGFR-TKI）或雷帕霉素抑制剂（mTORi）靶向治疗的未选患者转移性透明细胞肾细胞癌患者的疗效：单一机构经验
7. Metformin Impairs Vascular Endothelial Recovery After Stent Placement in the Setting of Locally Eluted Mammalian Target of Rapamycin Inhibitors Via S6 Kinase-Dependent Inhibition of Cell Proliferation [O] . Habib Anwer, Karmali Vinit, Polavarapu Rohini, 2013

机译：二甲双胍通过S6激酶依赖性抑制细胞增殖抑制雷帕霉素抑制剂局部洗脱的哺乳动物靶点的支架放置后损害血管内皮的恢复

Metformin Impairs Vascular Endothelial Recovery After Stent Placementin the Setting of Locally Eluted Mammalian Target of Rapamycin Inhibitors Via S6Kinase-Dependent Inhibition of Cell Proliferation

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