5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit Synaptic Dysfunction and Neuropathology in a Mouse Model of Alzheimer’s Disease

摘要

Background5-lipoxygenase activating protein (FLAP) is abundantly present in the central nervous system. Although its function has been extensively interrogated in the context of peripheral inflammation, novel roles for this protein are emerging in the central nervous system. The objective of our study was to investigate the functional role that FLAP plays in a mouse model of Alzheimer’s disease (AD) with plaques and tangles (i.e., 3×Tg mice).