Motor System Plasticity in Stroke Models: Intrinsically Use-dependent Unreliably Useful

摘要

Background and PurposeThe natural response to disability in one limb is to learn new ways of using the other limb. This compensatory behavioral strategy after stroke has long been thought to contribute to persistent dysfunction in the paretic limb by encouraging its disuse. Our recent findings suggest that it goes beyond the encouragement of disuse to disrupt neural substrates of paretic limb functional improvements.