Pilot Controlled Trial of the Adherence Readiness Program: An Intervention to Assess and Sustain HIV Antiretroviral Adherence Readiness

摘要

To pilot the Adherence Readiness Program, 60 patients planning to start HIV antiretrovirals were assigned to usual care (n=31) or the intervention (n=29), of whom 54 started antiretrovirals and were followed for up to 24 weeks. At Week 24, the intervention had a large effect (50.0% vs. 16.7%, d=.75) on optimal dose-timing (85+% doses taken on time) and small effect (54.2% vs. 43.3%, d=.22) on optimal dose-taking (85+% doses taken) electronically monitored adherence, and medium effect on undetectable viral load (62%.5% vs. 43.4%, d= .41), compared to usual care. These intervention benefits on adherence and viral suppression warrant further investigation.