Bisgma Stimulates Prostaglandin E2 Production in Macrophages via Cyclooxygenase-2 Cytosolic Phospholipase A2 and Mitogen-Activated Protein Kinases Family

摘要

BackgroundBisphenol A-glycidyl-methacrylate (BisGMA) employs as a monomer in dental resins. The leakage of BisGMA from composite resins into the peripheral environment can result in inflammation via macrophage activation. Prostaglandin E2 (PGE2) is a key regulator of immunopathology in inflammatory reactions. Little is known about the mechanisms of BisGMA-induced PGE2 expression in macrophage. The aim of this study was to evaluate the signal transduction pathways of BisGMA-induced PGE2 production in murine RAW264.7 macrophages.