Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of AlkylGrignard Reagents and Identification of Selective Anti-Breast Cancer Agents

摘要

β-Hydrogen-containing alkyl Grignard reagents were used in a stereospecific nickel-catalyzed cross-coupling reaction to form sp³–sp³ carbon–carbon bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells.