Effects of the Neuroactive Steroid Allopregnanolone on Intracranial Self-Stimulation in C57BL/6J Mice

摘要

RationaleThe neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) has effects on reward-related behaviors in mice and rats that suggest that it may activate brain reward circuits. Intracranial self-stimulation (ICSS) is an operant behavioral technique that detects changes in the sensitivity of brain reward circuitry following drug administration.