Endocrine Biomarkers and Symptom Clusters during the Menopausal Transition and Early Postmenopause: Observations from the Seattle Midlife Womens Health Study

摘要

ObjectiveDuring the menopausal transition and early postmenopause participants in the Seattle Midlife Women's Health Study (SMWHS) were likely to belong to one of three symptom severity classes: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (High-severity Hot Flash); moderate levels of all but hot flashes (Moderate Severity); and low levels of all (Low Severity). We tested models of differential effects of hypothalamic-pituitary-ovarian (HPO), hypothalamic-pituitary-adrenal (HPA), and autonomic nervous system (ANS) biomarkers on the three symptom severity classes.