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The Alzheimer’s Prevention Initiative composite cognitive test score: Sample size estimates for the evaluation of preclinical Alzheimer’s disease treatments in presenilin 1 E280A mutation carriers

机译：阿尔茨海默氏症预防倡议综合认知测试成绩：评估早老素1 E280A突变携带者临床前阿尔茨海默氏病治疗的样本量估计

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ObjectiveThere is a need to identify a cognitive composite that is sensitive to tracking preclinical AD decline to be used as a primary endpoint in treatment trials.

机译：目的需要确定一种对追踪临床前AD下降敏感的认知复合物，以用作治疗试验的主要终点。

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期刊名称 other
作者
Napatkamon Ayutyanont; Jessica B. Langbaum; Suzanne B. Hendrix; Kewei Chen; Adam S. Fleisher; Michel Friesenhahn; Michael Ward; Camilo Aguirre; Natalia Acosta-Baena; Lucìa Madrigal; Claudia Muñoz; Victoria Tirado; Sonia Moreno; Pierre N. Tariot; Francisco Lopera; Eric M. Reiman;
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年(卷),期 -1(75),6
年度 -1
页码 652–660
总页数 21
原文格式 PDF
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关键词
composite cognitive score API Alzheimer’s Prevention Initiative E280A PSEN1 presenilin1 sample size preclinical cognitively unimpaired autosomal dominant ADAD;

机译：综合认知评分;API;阿尔茨海默氏症预防计划;E280A;PSEN1;早老素1;样本量;临床前;无认知障碍;常染色体显性;ADAD;

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专利

1. The Alzheimer's prevention initiative composite cognitive test score: Sample size estimates for the evaluation of preclinical Alzheimer's disease treatments in presenilin 1 E280A mutation carriers [J] . AyutyanontN., LangbaumJ.B.S., HendrixS.B., The journal of clinical psychiatry . 2014,第6期

机译：阿尔茨海默氏症预防倡议综合认知测试评分：评估早老素1 E280A突变携带者临床前阿尔茨海默氏病治疗的样本量估计
2. Dual task abilities as a possible preclinical marker of Alzheimer's disease in carriers of the E280A presenilin-1 mutation [J] . MacPhersonS.E., ParraM.A., MorenoS., Journal of the International Neuropsychological Society: JINS . 2012,第2期

机译：双重任务能力可能是E280A presenilin-1突变携带者中阿尔茨海默氏病的临床前标记
3. The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease [J] . Jessica B. Langbaum, Noel N. Ellison, Angelika Caputo, Alzheimer s Research & Therapy . 2020,第1期

机译：Alzheimer的预防倡议复合认知测试：一种追踪临床前阿尔茨海默病的认知下降的实用措施
4. Effective Connectivity Changes in Presymptomatie Alzheimer's Disease with E280A Presenilin-1 Mutation Gene [C] . J. Ochoa, F. Sanchez, C. Tobon Latin American Congress on Biomedical Engineering . 2015

机译：Barymptomatie Alzheimer疾病的有效连通性变化e280a presenilin-1突变基因
5. Modeling clinically heterogeneous Alzheimer's disease-linked Presenilin mutations with transgenic Drosophila. [D] . Seidner, Glen Alan. 2006

机译：用转基因果蝇对临床上异质的阿尔茨海默氏病相关的早老素突变进行建模。
6. The Alzheimers Prevention Initiative Autosomal-Dominant Alzheimers Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimers disease including a placebo-treated noncarrier cohort [O] . Pierre N. Tariot, Francisco Lopera, Jessica B. Langbaum, 2018

机译：阿尔茨海默氏病预防计划常染色体显性阿尔茨海默氏病试验：在临床前PSEN1 E280A突变携带者中使用克雷珠单抗与安慰剂的研究以评估在常染色体显性阿尔茨海默氏病（包括安慰剂治疗的非携带者队列）中的疗效和安全性
7. Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease [O] . De Strooper, Bart 2007

机译：阿尔茨海默氏病中功能丧失的早老素突变。早老素突变在阿尔茨海默病中的作用的要点

The Alzheimer’s Prevention Initiative composite cognitive test score: Sample size estimates for the evaluation of preclinical Alzheimer’s disease treatments in presenilin 1 E280A mutation carriers

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