Neuroblastoma killing properties of V-delta 2 and V-delta2 negative gamma delta T cells following expansion by artificial antigen presenting cells

摘要

PurposeThe majority of circulating human γδT lymphocytes are of the Vγ9Vδ2 lineage, and have TCR specificity for non-peptide phosphoantigens. Previous attempts to stimulate and expand these cells have therefore focussed on stimulation using ligands of the Vγ9Vδ2 receptor, whilst relatively little is known about variant blood γδT subsets and their potential role in cancer immunotherapy.