A Murine Abdominal Aortic Aneurysm Model by Orthotopic Allograft Transplantation of Elastase-treated Abdominal Aorta

摘要

ObjectiveMurine models have proven instrumental in studying various aspects of abdominal aortic aneurysm (AAA) ranging from identification of underlying pathophysiology to the development of novel therapeutic strategies. In the current study, we describe a new model in which an elastase-treated donor aorta is transplanted to a recipient mouse and allowed to progress to aneurysm. We hypothesized that by transplanting an elastase-treated abdominal aorta of one genotype to a recipient mouse of a different genotype, one can differentiate pathophysiological factors that are intrinsic to the aortic wall from those stemming from circulation and other organs.