Hepatotoxicity in a 52-week randomized trial of short-term versus long-term treatment with buprenorphinealoxone in HIV-negative injection opioid users in China and Thailand

摘要

BackgroundBuprenorphinealoxone (BUP/NX), an effective treatment for opioid dependence, has been implicated in hepatic toxicity. However, as persons taking BUP/NX have multiple hepatic risk factors, comparative data are needed to quantify the risk of hepatoxicity with BUP/NX.