Photo-induced reduction of Pt(IV) within an anti-proliferative Pt(IV)-texaphyrin conjugate

摘要

In an effort to increase the stability and control the platinum reactivity of platinum-texaphyrin conjugates, two Pt(IV) conjugates (4 and 5, ) were designed, synthesized, and studied for their ability to form DNA adducts. They were also tested for their anti-proliferative effects using wild-type and platinum-resistant human ovarian cancer cell lines (A2780 and 2780CP, respectively). In comparison to an analogous first generation Pt(II)-texaphyrin chimera (2, ), conjugate 4 provided increased stability in aqueous environments.Structures of compounds considered in this study.