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mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matchingon-matching-to-sample task

机译：mGluR5正变构调制及其对大鼠操作性延迟匹配/不匹配样本任务中MK-801诱导的集合移位障碍的影响

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摘要

RationalePositive allosteric modulators (PAMs) of type 5 metabotropic glutamate receptors (mGluR5) exert pro-cognitive effects in animal models of various neuropsychiatric diseases. However, few studies to date have examined ability of mGluR5 PAMs to reverse cognitive deficits in operant delayed matchingon-matching-to-sample (DMS/DNMS) tasks.

机译：原理5型代谢型谷氨酸受体（mGluR5）的正变构调节剂（PAM）在各种神经精神疾病的动物模型中发挥促认知作用。然而，迄今为止，几乎没有研究检查了mGluR5 PAM在逆向操作的延迟匹配/不匹配样本（DMS / DNMS）任务中逆转认知缺陷的能力。

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期刊名称 other
作者
Amber L. LaCrosse; Brian T. Burrows; Rachel M. Angulo; Phoebe R. Conrad; Sarah M. Himes; Nordia Mathews; Scott A. Wegner; Sara B. Taylor; M. Foster Olive;
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作者单位

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年(卷),期 -1(232),1
年度 -1
页码 251–258
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
operant set-shifting type 5 metabotropic glutamate receptor N-methyl-D-aspartate receptor cognitive impairment match-to-sample schizophrenia;

机译：操作者位移;5型代谢型谷氨酸受体;N-甲基-D-天冬氨酸受体;认知障碍;样本匹配;精神分裂症;

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1. mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matchingon-matching-to-sample task [J] . LaCrosse Amber L., Burrows Brian T., Angulo Rachel M., Psychopharmacology . 2015,第1期

机译：mGluR5正变构调制及其对大鼠操作性延迟匹配/不匹配样本任务中MK-801诱导的集合移位障碍的影响
2. Different MK-801 administration schedules induce mild to severe learning impairments in an operant conditioning task: Role of buspirone and risperidone in ameliorating these cognitive deficits [J] . RapanelliM., FrickL.R., Bernardez-VidalM., Behavioural Brain Research: An International Journal . 2013,第Null期

机译：不同的MK-801给药方案在操作性调节任务中引起轻度至重度学习障碍：丁螺环酮和利培酮在缓解这些认知缺陷中的作用
3. PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats [J] . McLeanS.L., IdrisN.F., GraysonB., Journal of psychopharmacology . 2012,第9期

机译：PNU-120596是α7烟碱乙酰胆碱受体的正变构调节剂，可逆转亚慢性苯环利定诱发的雌性大鼠注意力转移中的认知功能障碍
4. Network-based static output feedback tracking control for a class of systems using the positive effects of network-induced delays [C] . Zhang, Dawei American Control Conference;ACC . 2012

机译：利用网络引起的延迟的积极影响，对一类系统进行基于网络的静态输出反馈跟踪控制
5. The Durational Effects of a Free Operant Condition on Automatically Maintained Stereotypic Behavior and Discrete Trial Task Responding [D] . Young, Shikika. 2015

机译：自动维护陈规定型行为和离散试验任务响应的自由操作条件的持久影响
6. Testosterone impairs the acquisition of an operant delayed alternation task in male rats [O] . Steven L. Neese, Susan L. Schantz -1

机译：睾酮损害在雄性大鼠中采集操作延迟交替任务
7. mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample task [O] . Amber L. LaCrosse, Brian T. Burrows, Rachel M. Angulo, 2014

机译：MGLUR5积极变构调制及其对大鼠延迟匹配/非匹配对样本任务中的MK-801诱导设定损伤的影响。

mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matchingon-matching-to-sample task

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