Non-rigid registration of serial dedicated breast CT longitudinal dedicated breast CT and PET/CT images using the diffeomorphic demons method

摘要

Rationale and ObjectivesDedicated breast CT and PET/CT scanners provide detailed 3D anatomical and functional imaging datasets and are currently being investigated for applications in breast cancer management such as diagnosis, monitoring response to therapy and radiation therapy planning. Our objective was to evaluate the performance of the diffeomorphic demons (DD) non-rigid image registration method to spatially align 3D serial (pre- and post-contrast) dedicated breast computed tomography (CT), and longitudinally-acquired dedicated 3D breast CT and positron emission tomography (PET)/CT images.