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Radiation Dosimetry and Biodistribution of the Translocator Protein Radiotracer 11CDAA1106 Determined with PET/CT in Healthy Human Volunteers

机译：PET / CT测定健康人体志愿者中易位蛋白放射性示踪剂11C DAA1106的辐射剂量和生物分布

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IntroductionWhen microglia become activated (an integral part of neuroinflammation), cellular morphology changes and expression of translocator protein (TSPO) 18 kDa is increased. Over the past several years, [¹¹C]DAA1106 has emerged as a reliable radiotracer for labeling TSPO with high affinity during positron emission tomography (PET) scanning. While [¹¹C]DAA1106 PET scanning has been used in several research studies, a radiation dosimetry study of this radiotracer in humans has not yet been published.

机译：简介小胶质细胞激活后（神经炎症的组成部分），细胞形态发生变化，18 kDa的转运蛋白（TSPO）表达增加。在过去的几年中，[^{11 C] DAA1106已经成为在正电子发射断层扫描（PET）扫描过程中以高亲和力标记TSPO的可靠放射性示踪剂。尽管[^{11 C] DAA1106 PET扫描已用于多项研究，但该放射性示踪剂在人体中的辐射剂量学研究尚未发表。}}

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期刊名称 other
作者
Arthur L. Brody; Kyoji Okita; Jennifer Shieh; Lidia Liang; Robert Hubert; Michael Mamoun; Judah Farahi; Mark A. Mandelkern;
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作者单位

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年(卷),期 -1(41),10
年度 -1
页码 871–875
总页数 12
原文格式 PDF
正文语种
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关键词
sup11/supCDAA1106 positron emission tomography dosimetry neuroinflammation translocator protein review;

机译：sup 11 / sup C DAA1106;正电子发射断层扫描;剂量测定;神经炎症;易位蛋白;综述;

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专利

1. Radiation dosimetry and biodistribution of the translocator protein radiotracer [C-11]DAA1106 determined with PET/CT in healthy human volunteers [J] . Brody Arthur L., Okita Kyoji, Shieh Jennifer, Nuclear Medicine and Biology . 2014 ,第10期

机译：PET / CT测定健康人志愿者中易位蛋白放射性示踪剂[C-11] DAA1106的辐射剂量和生物分布
2. Biodistribution and Radiation Dosimetry of the Enterobacteriaceae-Specific Imaging Probe [F-18]Fluorodeoxysorbitol Determined by PET/CT in Healthy Human Volunteers [J] . Zhu Wenjia, Yao Shaobo, Xing Haiqun, Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2016 ,第5期

机译：PET / CT测定健康人体志愿者中肠杆菌科特定成像探针[F-18]氟脱氧山梨醇的生物分布和辐射剂量。
3. Biodistribution and Radiation Dosimetry of the Carbonic Anhydrase IX Imaging Agent [(18) F]VM4-037 Determined from PET/CT Scans in Healthy Volunteers [J] . Doss Mohan, Kolb Hartmuth C., Walsh Joseph C., Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2014 ,第5期

机译：从健康志愿者的PET / CT扫描确定碳酸酐酶IX成像剂[（18）F] VM4-037的生物分布和辐射剂量。
4. Improved synthesis, biodistribution and human radiation dosimetry estimation of 6-F- 18fluoro-L-DOPA [C] . The First China-Japan-Korea conference of nuclear medicine . 2002

机译：改进的6- F-18氟-L-DOPA的合成，生物分布和人体辐射剂量学估计
5. Compartmental modeling and dosimetry of in vivo metabolic studies of leucine and three secretory proteins in humans using radioactive tracers. [D] . Venkatakrishnan, Vaidehi. 1995

机译：使用放射性示踪剂对人体中亮氨酸和三种分泌蛋白的体内代谢研究进行的区室建模和剂量测定。
6. Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand 18F-PBR06 to Image Translocator Protein (18 kDa) [O] . Yota Fujimura, Yasuyuki Kimura, Fabrice G. Siméon, -1

机译：新型PET配体18F-PBR06在人体内对图像转运蛋白（18 kDa）的生物分布和辐射剂量测定。
7. Radiation dosimetry and biodistribution of the translocator protein radiotracer 11CDAA1106 determined with PET/CT in healthy human volunteers [O] . Arthur L. Brody, Kyoji Okita, Jennifer Shieh, 2014

机译：易燃剂蛋白放射酸的辐射剂量和生物分布，用PET / CT在健康人志愿者中测定DAA1106

Radiation Dosimetry and Biodistribution of the Translocator Protein Radiotracer 11CDAA1106 Determined with PET/CT in Healthy Human Volunteers

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