Relationships between times to testosterone and prostate-specific antigen rises during the first off treatment interval of intermittent androgen deprivation are prognostic for castration-resistance in men with non-metastatic prostate cancer

摘要

MicroabstractThe kinetics and relationships between testosterone (T) and prostate-specific antigen (PSA) during the first off-treatment interval in men with non-metastatic prostate cancer treated prospectively on a clinical trial of intermittent androgen deprivation were analyzed. Time to PSA rise and time to PSA rise after first T>50 ng/dL were prognostic for progression to castration-resistance.