The Nucleic Acid Scavenger Dendrimer Polyamidoamine Third-Generation Dendrimer Inhibits Fibroblast Activation and Inhibits Granulation Tissue Contraction

摘要

BackgroundPathologic cutaneous scarring affects over 40 million people worldwide and costs billions of dollars annually. Understanding mechanisms of fibroblast activation and granulation tissue contraction is the first step toward preventing pathologic scarring. The authors hypothesize that nucleic acids increase fibroblast activation and cause granulation tissue contraction and sequestration of nucleic acids by application of a nucleic acid scavenger dendrimer, polyamidoamine third-generation dendrimer, will decrease pathologic scarring.