Oxidation-responsive Eu2+/3+-liposomal contrast agent for dual-mode magnetic resonance imaging

摘要

An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu²⁺ and liposomes. Positive contrast enhancement was observed with Eu²⁺, and chemical exchange saturation transfer was observed before and after oxidation of Eu²⁺. Orthogonal detection modes render the concentration of Eu inconsequential to molecular information provided through imaging.