Sirolimus-eluting dextran and polyglutamic acid hybrid coatings on AZ31 for stent applications

摘要

Magnesium (Mg)-based cardiovascular stents are promising candidate as the next generation of novel stents. Clinical studies have revealed encouraging outcomes, but late restenosis and thrombogenesis still largely exist. Blood and vascular biocompatible coatings with drug-eluting features could be the solution to such problems.ObjectiveThis study was to investigate the feasibility of a three-layer hybrid coating on Mg alloy AZ31 with sirolimus-eluting feature for cardiovascular stent application.