The high feature-dimension and low sample-size problem is one of the major challenges in the study of computer-aided Alzheimer’s Disease (AD) diagnosis. To circumvent this problem, feature selection and subspace learning have been playing core roles in literature. Generally, feature selection methods are preferable in clinical applications due to their ease for interpretation, but subspace learning methods can usually achieve more promising results. In this paper, we combine two different methodological approaches to discriminative feature selection in a unified framework. Specifically, we utilize two subspace learning methods, namely, Linear Discriminant Analysis (LDA) and Locality Preserving Projection (LPP), which have proven their effectiveness in a variety of fields, to select class-discriminative and noise-resistant features. Unlike previous methods in neuroimaging studies that mostly focused on a binary classification, the proposed feature selection method is further applicable for multi-class classification in AD diagnosis. Extensive experiments on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset show the effectiveness of the proposed method over other state-of-the-art methods.
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