The Helicobacter species in the gut microbiota comprise Helicobacter pylori (H pylori) and enterohepatic Helicobacter species (EHS), which can colonize the intestinal mucosa. However, it is unclear whether EHS are associated with inflammatory bowel disease (IBD). Therefore, we conducted this meta-analysis to examine the association between EHS and IBD.PubMed, Scopus, Cochrane Library, and Web of Science databases, as well as abstracts from conference proceedings were searched to identify studies that used polymerase chain reaction to detect Helicobacter species in intestinal samples from patients with IBD.After screening, we carefully reviewed 20 of the 2955 identified studies, and performed a meta-analysis of the findings from 14 studies (11 adult studies and 3 pediatric studies) using STATA v12.0. These studies evaluated 1407 individuals, including 433 patients with Crohn's disease, 306 patients with ulcerative colitis, and 668 controls. The prevalence of Helicobacter species was higher among the patients with IBD, compared to that among the controls, which corresponded to a pooled risk ratio (RR) of 1.59 (95% confidence interval [CI]: 1.12–2.27). The RRs for adult and pediatric patients with IBD were 1.61 (95% CI: 1.03–2.52) and 1.76 (95% CI: 1.17–2.64), respectively. Compared to the controls, the patients with IBD tended to have a higher prevalence of EHS in the intestinal mucosa (RR: 2.01, 95% CI: 1.36–2.98), although the prevalence of H pylori was not significantly higher (RR: 1.22, 95% CI: 0.77–1.95). Compared to the controls, the RRs for EHS in patients with Crohn's disease and ulcerative colitis were 1.72 (95% CI: 1.20–2.47) and 3.27 (95% CI: 0.93–11.44), respectively.It appears that EHS was associated with IBD, while intestinal H pylori infection was not significantly associated with IBD. Further studies are needed to determine the involvement of EHS in the microbiological etiology of IBD.
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机译:肠道菌群中的幽门螺杆菌包括幽门螺杆菌(H. pylori)和肠肝幽门螺杆菌(EHS),它们可以在肠道粘膜上定居。但是,尚不清楚EHS是否与炎症性肠病(IBD)相关。因此,我们进行了这项荟萃分析,以检查EHS与IBD之间的关联.PubMed,Scopus,Cochrane图书馆和Web of Science数据库以及会议记录的摘要均经过检索,以鉴定使用聚合酶链反应检测幽门螺杆菌的研究。筛选后,我们仔细审查了2955个已鉴定研究中的20个,并使用STATA v12.0对14个研究(11个成人研究和3个儿科研究)的发现进行了荟萃分析。这些研究评估了1407个人,包括433例克罗恩病患者,306例溃疡性结肠炎患者和668例对照。与对照组相比,IBD患者中幽门螺杆菌的患病率更高,对应的风险比(RR)为1.59(95%置信区间[CI]:1.12-2.27)。成人和小儿IBD患者的RR分别为1.61(95%CI:1.03–2.52)和1.76(95%CI:1.17–2.64)。与对照组相比,IBD患者的肠黏膜EHS患病率较高(RR:2.01,95%CI:1.36-2.98),尽管幽门螺杆菌的患病率并不明显较高(RR:1.22, 95%CI:0.77-1.95)。与对照组相比,克罗恩病和溃疡性结肠炎患者的EHS的RR分别为1.72(95%CI:1.20–2.47)和3.27(95%CI:0.93–11.44)。似乎EHS与IBD相关,而肠道幽门螺杆菌感染与IBD并没有显着相关。为了确定EHS是否与IBD的微生物病因有关,需要做进一步的研究。
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