Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome

摘要

ObjectivePhysiologic dead space is associated with mortality in acute respiratory distress syndrome (ARDS), but its measurement is cumbersome. Alveolar dead space fraction (AVDSf) relies on the difference between arterial and end-tidal carbon dioxide (AVDSf = (PaCO2 − PETCO2)/PaCO2). We aimed to assess the relationship between AVDSf and mortality in a cohort of children meeting criteria for ARDS (both Berlin 2012 and AECC 1994 acute lung injury) and pediatric ARDS (PARDS, as defined by PALICC in 2015).