TLR2-expressing macrophages are required and sufficient for rhinovirus-induced airway inflammation

摘要

BackgroundWe have shown that rhinovirus (RV), a cause of asthma exacerbations, colocalizes with CD68- and CD11b-positive airway macrophages following experimental infection in humans. We have also shown that RV-induced cytokine expression is abolished in TLR2−/− bone marrow-derived macrophages.