Rationale of Technical Requirements for NRG-BR001: The First NCI-Sponsored Trial of SBRT for the Treatment of Multiple Metastases

摘要

IntroductionIn 2014, the NRG Oncology Group initiated the first NCI-sponsored, phase I clinical trial of SBRT for the treatment of multiple metastases in multiple organ sites (XXXX; NCTXXX). The primary endpoint is to test the safety of SBRT for the treatment of multiple lesions (–) in several anatomic sites in a multi-institutional setting. Because of the technical challenges inherent to treating multiple lesions as their spatial separation decreases, we present the technical requirements for NRG-XXXX and the rationale for their selection.