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Time to Definitive Health-Related Quality of Life Score Deterioration in Patients with Resectable Metastatic Colorectal Cancer Treated with FOLFOX4 versus Sequential Dose-Dense FOLFOX7 followed by FOLFIRI: The MIROX Randomized Phase III Trial

机译：FOLFOX4与序贯剂量密集型FOLFOX7联合FOLFIRI联合治疗的可切除转移性结直肠癌患者达到确定的健康相关生活质量评分恶化的时间：MIROX随机III期试验

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PurposeWe previously showed that a sequential chemotherapy with dose-dense oxaliplatin (FOLFOX7) and irinotecan (FOLFIRI; irinotecan plus 5-fluorouracil/leucovorin) is not superior to FOLFOX4 in patients at advanced stage of colorectal cancer with liver metastases. Here we aimed to determine whether time to health-related quality of life (HRQoL) score definitive deterioration (TUDD) differs by study arm.

机译：目的我们先前显示，在患有肝转移的大肠癌晚期患者中，采用剂量密集的奥沙利铂（FOLFOX7）和伊立替康（FOLFIRI;伊立替康加5-氟尿嘧啶/亚叶酸）的顺序化疗并不优于FOLFOX4。在这里，我们旨在确定与研究相关的与健康相关的生活质量（HRQoL）分数最终恶化（TUDD）的时间是否不同。

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期刊名称 other
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Zeinab Hamidou; Benoist Chibaudel; Mohamed Hebbar; Marine Hug de Larauze; Thierry André; Christophe Louvet; David Brusquant; Marie-Line Garcia-Larnicol; Aimery de Gramont; Franck Bonnetain;
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年(卷),期 -1(11),6
年度 -1
页码 e0157067
总页数 14
原文格式 PDF
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1. FOLFOX4 versus sequential dose-dense FOLFOX7 followed by FOLFIRI in patients with resectable metastatic colorectal cancer (MIROX): a pragmatic approach to chemotherapy timing with perioperative or postoperative chemotherapy from an open-label, randomized phase III trial [J] . Hebbar M., Chibaudel B., Andre T., Annals of oncology: official journal of the European Society for Medical Oncology . 2015,第2期

机译：可切除的转移性结直肠癌（MIROX）患者中FOLFOX4与序贯剂量密集型FOLFOX7继之以FOLFIRI的比较：一项开放性随机III期临床试验的一种实用的化疗围手术期或术后化疗时机方法
2. FOLFOX4 versus sequential dose-dense FOLFOX7 followed by FOLFIRI in patients with resectable metastatic colorectal cancer (MIROX): a pragmatic approach to chemotherapy timing with perioperative or postoperative chemotherapy from an open-label, randomized phase III trial (vol 26, pg 340, 2015) [J] . Hebbar M., Chibaudel B., Andre T., Annals of oncology: official journal of the European Society for Medical Oncology . 2015,第5期

机译：可切除的转移性结直肠癌（MIROX）患者中的FOLFOX4与序贯剂量密集型FOLFOX7继之以FOLFIRI：从开放标签，随机III期试验（第26卷，第340页，2015年）进行围手术期或术后化疗的化疗时机的实用方法）
3. 1108 POSTER Health-related quality of life (HRQOL) and kidney cancer-related symptoms in patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib versus interferon (IFN)-alfa: results for European and US subsample analyses in a randomized, multinational phase III trial [J] . D.Cella, J.Z.Li, A.G.Bushmakin, European Journal of Cancer Supplements . 2007,第4期

机译：1108海报舒尼替尼与干扰素（α）治疗的转移性肾细胞癌（mRCC）患者的健康相关生活质量（HRQOL）和肾癌相关症状：欧洲和美国随机，多国三期试验
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机译：顺序FOLFIRI.3 +吉西他滨改善转移性胰腺腺癌患者无生命恶化的健康相关生存质量：一项随机的II期临床试验
5. Time to Definitive Health-Related Quality of Life Score Deterioration in Patients with Resectable Metastatic Colorectal Cancer Treated with FOLFOX4 versus Sequential Dose-Dense FOLFOX7 followed by FOLFIRI: The MIROX Randomized Phase III Trial. [O] . Zeinab Hamidou, Benoist Chibaudel, Mohamed Hebbar, 2016

机译：用FOLFOX4与序贯剂量密集型FOLFOX7治疗可切除的转移性结直肠癌患者的确定健康相关生活质量评分恶化的时间随后是FOLFIRI：mIROX随机III期试验。

Time to Definitive Health-Related Quality of Life Score Deterioration in Patients with Resectable Metastatic Colorectal Cancer Treated with FOLFOX4 versus Sequential Dose-Dense FOLFOX7 followed by FOLFIRI: The MIROX Randomized Phase III Trial

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