Neuroimaging of Translocator Protein in Patients with Systemic Lupus Erythematosus: A Pilot Study Using 11CDPA-713 Positron Emission Tomography

摘要

ObjectiveInflammation secondary to autoantibody-mediated effects occurring in multiple organs is a hallmark of systemic lupus erythematosus (SLE). The inflammatory response to SLE-mediated damage in brain parenchyma has been postulated in both normal and cognitively impaired individuals. Our goal is to use molecular imaging to investigate the distribution of the mitochondrial translocator protein (TSPO) within brain, which is upregulated during glial cell activation and considered as a marker of brain injury and repair.