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From Bench-Top to Bedside: A Prospective In Vitro Antibiotic Combination Testing (iACT) Service to Guide the Selection of Rationally Optimized Antimicrobial Combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB)

机译：从台式到床头：前瞻性体外抗生素组合测试（iACT）服务指导针对广泛耐药性（XDR）革兰氏阴性菌（GNB）合理选择最佳抗菌组合的选择

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IntroductionCombination therapy is increasingly utilized against extensively-drug resistant (XDR) Gram negative bacteria (GNB). However, choosing a combination can be problematic as effective combinations are often strain-specific. An in vitro antibiotic combination testing (iACT) service, aimed to guide the selection of individualized and rationally optimized combination regimens within 48 hours, was developed. We described the role and feasibility of the iACT service in guiding individualized antibiotic combination selection in patients with XDR-GNB infections.

机译：简介联合疗法越来越多地用于抵抗广泛耐药性（XDR）的革兰氏阴性细菌（GNB）。但是，选择一个组合可能会出现问题，因为有效的组合通常是特定于应变的。开发了一种体外抗生素联合检测服务（iACT），旨在指导在48小时内选择个性化和合理优化的联合治疗方案。我们描述了iACT服务在指导XDR-GNB感染患者个体化抗生素组合选择中的作用和可行性。

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Yiying Cai; Nathalie Grace Chua; Tze-Peng Lim; Jocelyn Qi-Min Teo; Winnie Lee; Asok Kurup; Tse-Hsien Koh; Thuan-Tong Tan; Andrea L. Kwa;
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年(卷),期 -1(11),7
年度 -1
页码 e0158740
总页数 16
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1. High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. [J] . Shields RK, Kwak EJ, Potoski BA, Diagnostic microbiology and infectious disease . 2011,第2期

机译：在感染了广泛耐药性鲍曼不动杆菌的实体器官移植接受者中，高死亡率：使用体外抗生素联合测试确定碳青霉烯和粘菌素的组合是一种有效的治疗方案。
2. Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections [J] . Mangal Sharad, Huang Jiayang, Shetty Nivedita, International Journal of Pharmaceutics . 2019,第期

机译：抗生素组分对体外细菌杀伤，物理化学性质，抗生素抗生素抗生素粉末制剂的体外细菌杀伤，物理化学性质，雾化和溶解
3. Combination therapy for extensively-drug resistant gram-negative bacteria [J] . Karaiskos Ilias, Antoniadou Anastasia, Giamarellou Helen Expert review of anti-infective therapy . 2017,第7a12期

机译：用于广泛毒性革兰阴性细菌的组合疗法
4. 2395. Mechanism-Based-Susceptibility Testing (MBST) Using Disc Diffusion Assays (DDA) to Guide Treatment of Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa (MDR-XDR-Pa) in a Cystic Fibrosis (CF) Lung Transplant Recipient; Are We Ready for Combination Therapy vs. MDR-XDR-Pa? [O] . Lilian M Abbo, Mohamad Yasmin, Steven H Marshall, -1

机译：2395.基于机理的药敏试验（MBST）使用椎间盘扩散测定法（DDA）指导囊性纤维化（CF）肺移植受者中对多药和广泛耐药的铜绿假单胞菌（MDR-XDR-Pa）的治疗；我们准备好进行联合治疗与MDR-XDR-Pa了吗？
5. From Bench-Top to Bedside: A Prospective In Vitro Antibiotic Combination Testing (iACT) Service to Guide the Selection of Rationally Optimized Antimicrobial Combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB). [O] . Yiying Cai, Nathalie Grace Chua, Tze-Peng Lim, 2016

机译：从台式到床边：前瞻性体外抗生素组合测试（iaCT）服务，以指导针对广泛耐药（XDR）革兰氏阴性细菌（GNB）选择合理优化的抗菌组合。

From Bench-Top to Bedside: A Prospective In Vitro Antibiotic Combination Testing (iACT) Service to Guide the Selection of Rationally Optimized Antimicrobial Combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB)

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