Microsecond and Nanosecond Polyproline II Helix Formation in Aqueous Nanodrops Measured by Mass Spectrometry

摘要

The 1.5 μs and <400 ns time constants for the formation of polyproline II helix structures in 21 and 16 residue peptides, respectively, are measured using rapid mixing from theta-glass emitters coupled with mass spectrometry. Results from these studies should serve as useful benchmarks for comparison with computational simulation results.