Can We Eliminate Neoadjuvant Chemoradiotherapy in favor of Neoadjuvant Multi-Agent Chemotherapy for select Stage II/III Rectal Adenocarcinomas: Analysis of the National Cancer Database

摘要

BACKGROUNDStage II and III rectal cancers have been effectively treated with neoadjuvant chemoradiotherapy (NCRT) followed by definitive resection. Advancements in surgical technique and systemic therapy have prompted investigation of neoadjuvant multi-agent chemotherapy (NMAC) regimens with the elimination of radiation (RT). The purpose of our study was to investigate factors predicting for the use of NCRT versus NMAC and compare outcomes using the National Cancer Data Base (NCDB) for select Stage II/III rectal cancers.