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Effect of Sodium-Glucose Co-Transporter 2 Inhibitor Dapagliflozin on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes

机译：钠-葡萄糖共转运蛋白2抑制剂达格列净对2型糖尿病动物模型中肾素-血管紧张素系统的影响

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BackgroundRenal renin-angiotensin system (RAS) activation is one of the important pathogenic mechanisms in the development of diabetic nephropathy in type 2 diabetes. The aim of this study was to investigate the effects of a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, dapagliflozin, on renal RAS in an animal model with type 2 diabetes.

机译：背景肾素-血管紧张素系统（RAS）的激活是2型糖尿病糖尿病肾病发展的重要致病机制之一。本研究的目的是研究2型糖尿病动物模型中钠葡萄糖共转运蛋白2（SGLT-2）抑制剂dapagliflozin对肾RAS的影响。

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期刊名称 other
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Seok Joon Shin; Sungjin Chung; Soo Jung Kim; Eun-Mi Lee; Young-Hye Yoo; Ji-Won Kim; Yu-Bae Ahn; Eun-Sook Kim; Sung-Dae Moon; Myung-Jun Kim; Seung-Hyun Ko;
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年(卷),期 -1(11),11
年度 -1
页码 e0165703
总页数 18
原文格式 PDF
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专利

1. Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in Japanese subjects without and with type 2 diabetes mellitus. [J] . Kasichayanula S, Chang M, Hasegawa M, Diabetes, obesity & metabolism . 2011,第4期

机译：dapagliflozin（一种新型的2型钠-葡萄糖共转运蛋白的选择性抑制剂）在没有和患有2型糖尿病的日本受试者中的药代动力学和药效学。
2. Effects of the sodium-glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and Stages 3b-4 chronic kidney disease (gfx350, 2018) [J] . Dekkers Claire C. J., Wheeler David C., Sjostrom C. David, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2018,第7期

机译：钠葡萄糖共转运蛋白抑制剂Dapagliflozin患者2型糖尿病患者3B-4慢性肾病（GFX350,2018）
3. Effects of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, and free omega-3 carboxylic acids on liver steatosis and hepatocyte damage biomarkers in Type 2 diabetes patients with non-alcoholic fatty liver disease [J] . Oscarsson Jan, Lundkvist Per, Jansson Per-Anders E., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：Dapagliflozin，钠葡萄糖共转运蛋白2抑制剂和自由ω-3羧酸对2型糖尿病患者非酒精性脂肪肝病患者的肝脏脂肪变性和肝细胞损伤生物标志物的影响
4. The Comparative Effect of Pomegranate Peel Extract and Dapagliflozin on Body Weight of Male Albino Wistar Rats with Type 2 Diabetes Mellitus [C] . Devi Trisna Ramadhani, Rafi Amanda Rezkia Amradani, Mila Ulfia Annual Basic Science International Conference . 2019

机译：石榴果皮提取物和Dapagliflozin对2型糖尿病雄性白化Wistar大鼠体重的对比作用
5. Responses of renal hemodynamics and tubular functions to acute sodium-glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats [D] . Tuba Musarrat Ansary 2019

机译：非糖尿病麻醉大鼠肾血流动力学和肾小管功能对急性钠-葡萄糖共转运蛋白2抑制剂给药的反应
6. Effect of the Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin on Genitourinary Infection in an Animal Model of Type 2 Diabetes [O] . Jin Bong Choi, Je Mo Yoo, Ye-Jee Lee, 2020

机译：钠葡萄糖共转运蛋白2抑制剂Dapagliflozin对2型糖尿病动物模型泌尿生殖系统感染的影响
7. Effect of Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin, on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes. [O] . Seok Joon Shin, Sungjin Chung, Soo Jung Kim, 2016

机译：钠 - 葡萄糖共转运蛋白2抑制剂达帕格列净对2型糖尿病动物模型肾脏肾素 - 血管紧张素系统的影响。

Effect of Sodium-Glucose Co-Transporter 2 Inhibitor Dapagliflozin on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes

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