UNIQUE SPATIOTEMPORAL AND DYNAMIC GAIT COMPENSATIONS IN THE RAT MONOIODOACETATE INJECTION AND MEDIAL MENISCUS TRANSECTION MODELS OF KNEE OSTEOARTHRITIS

摘要

ObjectiveIn rodent osteoarthritis models, behavioral changes are often subtle and require highly sensitive methods to detect these changes. Gait analysis is one assay that may provide sensitive, quantitative measurement of these behavioral changes. To increase detection sensitivity of gait assessments relative to spatiotemporal gait collection alone, we combined our spatiotemporal and dynamic gait collection systems. Using this combined system, gait was assessed in the rat medial meniscus transection model and monoiodoacetate injection model of knee osteoarthritis.