Varying degrees of temporoparietal hypometabolism on FDG-PET reveal amyloid-positive logopenic primary progressive aphasia is not a homogeneous clinical entity

摘要

BackgroundThe logopenic variant of primary progressive aphasia (lvPPA) manifests due to a breakdown of the language network with prominent hypometabolism of the left temporoparietal region. LvPPA is strongly associated with amyloid deposition, yet there is question as to whether it is a homogeneous clinical entity.