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Nonparametric Two-Sample Tests of the Marginal Mark Distribution with Censored Marks

机译:带删失标记的边际标记分布的非参数两样本检验

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摘要

Occasionally, investigators collect auxiliary marks at the time of failure in a clinical study. Because the failure event may be censored at the end of the follow-up period, these marked endpoints are subject to induced censoring. We propose two new families of two-sample tests for the null hypothesis of no difference in mark-scale distribution that allows for arbitrary associations between mark and time. One family of proposed tests is a nonparametric extension of an existing semi-parametric linear test of the same null hypothesis while a second family of tests is based on novel marked rank processes. Simulation studies indicate that the proposed tests have the desired size and possess adequate statistical power to reject the null hypothesis under a simple change of location in the marginal mark distribution. When the marginal mark distribution has heavy tails, the proposed rank-based tests can be nearly twice as powerful as linear tests.
机译:在临床研究失败时,研究人员有时会收集辅助标记。由于失败事件可能会在随访期结束时进行检查,因此这些标记的端点会受到检查。对于标记规模分布无差异的零假设的零假设,我们提出了两个新的两样本检验系列,该零假设允许标记与时间之间的任意关联。一类建议的检验是对相同零假设的现有半参数线性检验的非参数扩展,而第二类检验则基于新颖的标记秩过程。仿真研究表明,所提出的检验具有所需的大小,并具有足够的统计能力,可以在边际标记分布中位置发生简单变化的情况下拒绝零假设。当边缘标记分布的尾巴很重时,建议的基于等级的测试的功能几乎是线性测试的两倍。

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