A Sterile 20-family kinase and its co-factor CCM-3 regulate contractile ring proteins on germline intercellular bridges

摘要

eTOC BlurbIntercellular bridges are proposed to arise from stabilization of a mitotic cytokinetic ring. Rehain-Bell et al. demonstrate that inhibition of non-muscle myosin II is a conserved mechanism of bridge stabilization and find that, in the C. elegans oogenic germline, this is mediated by GCK-1^{Ste-20 Kinase}, its co-factor CCM-3, and anillin proteins.