Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing

摘要

Correlations in activity across disparate brain regions during rest reveal functional networks in the brain. Although previous studies largely agree that there is an age-related decline in the “default mode network,” how age affects other resting-state networks, such as emotion-related networks, is still controversial. Here we used a dual regression approach to investigate age-related alterations in resting-state networks. The results revealed age-related disruptions in functional connectivity in all five identified cognitive networks, namely the default mode network, cognitive-auditory, cognitive-speech (or speech-related somatosensory) and right and left fronto-parietal networks, whereas such age effects were not observed in the three identified emotion networks. In addition, we observed age-related decline in functional connectivity in three visual and three motor/visuospatial networks. Older adults showed greater functional connectivity in regions outside four out of the five identified cognitive networks, consistent with the dedifferentiation effect previously observed in task-based fMRI studies. Both reduced within-network connectivity and increased out-of-network connectivity were correlated with poor cognitive performance, providing potential biomarkers for cognitive aging.