Age of Menopause and Fracture Risk in Post-Menopausal Women Randomized to Calcium + Vitamin D Hormone Therapy or the combination: Results from the Women’s Health Initiative Clinical Trials

摘要

OBJECTIVEWe previously reported that in the absence of hormone therapy (HT) or calcium/vitamin D (Ca/D) supplementation, earlier menopause age was associated with decreased bone mineral density (BMD) and increased fracture risk in healthy post-menopausal women. Treatment with HT and Ca/D are protective against fractures after menopause. In this analysis, we asked if age of menopause onset alters fracture risk in healthy post-menopausal women receiving HT, Ca/Vit D, or the combination.